ELISA DDB2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex(the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway(the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers(CPD), 6-4 photoproducts(6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition modµLe for the DCX(DDB1-CµL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CµL4-ROC1(also known as CµL4-DDB-ROC1 and CµL4-DDB-RBX1). The DDB1-CµL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CµL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair. Immunogen:damage-specific DNA binding protein 2, 48kDa Synonyms: Observed MW:55-60 kDa Uniprot ID:Q92466 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:500-1:2000; IF: 1:20-1:200 Gene ID:1643 Research Area:Epigenetics, Metabolism