ELISA DCUN1D1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cµLlin components of E3 cµLlin-RING ubiquitin ligase complexes. Acts by binding to cµLlin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8(UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cµLlin substrates(PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cµLlin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression(By similarity). Immunogen:DCN1, defective in cµLlin neddylation 1, domain containing 1(S. cerevisiae) Synonyms:DCUN1L1, RP42, SCCRO Observed MW:28 kDa Uniprot ID:Q96GG9 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:54165 Research Area:Metabolism