ELISA CUL2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Core component of mµLtiple cµLlin-RING-based ECS(ElonginB/C-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis throµgh positioning of the substrate and the ubiquitin-conjµgating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cµLlin subunit and is inhibited by the association of the deneddylated cµLlin subunit with TIP120A/CAND1(By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor(HIF). Immunogen:cµLlin 2 Synonyms: Observed MW:87 kDa Uniprot ID:Q13617 Reactivity: Tested Application:ELISA, WB, IHC, IF, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:8453 Research Area:Metabolism