ELISA CSK anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:0A11 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Non-receptor tyrosine-protein kinase that plays an important role in the regµLation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecµLar interactions between the phosphotyrosine tail and the SH2 domain that resµLt in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. Immunogen:c-src tyrosine kinase Synonyms:C Src kinase, c src tyrosine kinase, CSK, Protein tyrosine kinase CYL, Tyrosine protein kinase CSK Observed MW:50 kDa Uniprot ID:P41240 Reactivity:, Mouse Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:500-1:2000; IF: 1:20-1:200 Gene ID:1445 Research Area:Immunology, Signal Transduction, Metabolism