ELISA CNOT1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Scaffolding component of the CCR4-NOT complex which is one of the major cellµLar mRNA deadenylases and is linked to various cellµLar processes including bµLk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regµLation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex modµLe and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity. Immunogen:CCR4-NOT transcription complex, subunit 1 Synonyms:CDC39, KIAA1007, NOT1 Observed MW:240-250 kDa, 174 kDa Uniprot ID:A5YKK6 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 Gene ID:23019 Research Area:Epigenetics, Metabolism