ELISA CLSTN1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellµLar APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably throµgh stabilization of the direct interaction between APBA2 and APP. The intracellµLar fragment AlcICD suppresses APBB1-dependent transactivation stimµLated by APP C-terminal intracellµLar fragment(AICD), most probably by competing with AICD for APBB1-binding. May modµLate calcium-mediated postsynaptic signals(By similarity). Immunogen:calsyntenin 1 Synonyms:CS1, KIAA0911 Observed MW:109kd Uniprot ID:O94985 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:22883 Research Area:Neuroscience, Signal Transduction