ELISA CLSPN anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Immunogen:claspin homolog(Xenopus laevis) Synonyms: Observed MW:240 kDa Uniprot ID:Q9HAW4 Reactivity: Tested Application:ELISA, WB, IF, IP Recommended dilution:WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200 Gene ID:63967 Research Area: