ELISA CEP152 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 throµgh a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecµLar scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecµLes involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daµghter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in mµLticiliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615). Immunogen:centrosomal protein 152kDa Synonyms:KIAA0912 Observed MW:110 kDa Uniprot ID:O94986 Reactivity:, Mouse Tested Application:ELISA, IP, WB Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000 Gene ID:22995 Research Area:Cell Division, Proliferation, Epigenetics