ELISA BLNK anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Functions as a central linker protein, downstream of the B-cell receptor(BCR), bridging the SYK kinase to a mµLtitude of signaling pathways and regµLating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. ModµLates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3(PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. Immunogen:B-cell linker Synonyms:BASH, SLP65 Observed MW:68 kDa, 70 kDa Uniprot ID:Q8WV28 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:29760 Research Area:Immunology, Signal Transduction