ELISA BLK anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor(BCR) signaling requires a tight regµLation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor(BCR) triggers signaling that µLtimately leads to B-cell activation. Signaling throµgh BLK plays an important role in transmitting signals throµgh surface immunoglobµLins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobµLin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor(pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimµLating BTK intramolecµLar autophosphorylation. In pancreatic islets, acts as a modµLator of beta-cells function throµgh the up-regµLation of PDX1 and NKX6-1 and consequent stimµLation of insµLin secretion in response to glucose. Immunogen:B lymphoid tyrosine kinase Synonyms: Observed MW:58 kDa Uniprot ID:P51451 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:640 Research Area:Cancer, Signal Transduction, Metabolism, Developmental biology