ELISA BHLHE41 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcriptional repressor involved in the regµLation of the circadian rhythm by negatively regµLating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregµLatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regµLates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Immunogen:basic helix-loop-helix family, member e41 Synonyms:BHLHB3, DEC2, SHARP1 Observed MW:51 kDa, 75 kDa Uniprot ID:Q9C0J9 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:1000-1:2000 Gene ID:79365 Research Area:Neuroscience, Epigenetics, Metabolism, Developmental biology