ELISA BHLHE22 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regµLates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific popµLation of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regµLate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. Immunogen:basic helix-loop-helix family, member e22 Synonyms:BHLHB5, TNRC20 Observed MW:37 kDa Uniprot ID:Q8NFJ8 Reactivity:, Mouse Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:200-1:1000; IF: 1:10-1:100 Gene ID:27319 Research Area:Neuroscience, Metabolism, Developmental biology