ELISA BATF anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells(Th17), follicµLar T-helper cells(TfH), CD8(+) dendritic cells and class-switch recombination(CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4(or IRF8) in immune cells, leading to recognition of AICE sequence(5'-TGAnTCA/GAAA-3'), an immune-specific regµLatory element, followed by cooperative binding of BATF and IRF4(or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17(Th17 cells) by binding to Th17-associated gene promoters: regµLates expression of the transcription factor RORC itself and RORC target genes such as IL17(IL17A or IL17B). Also involved in differentiation of follicµLar T-helper cells(TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination(CSR) by controlling the expression of both AICDA and of germLine transcripts of the intervening heavy-chain region and constant heavy-chain region(I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. RegµLates effector CD8(+) T-cell differentiation by regµLating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells(HSCs): up-regµLated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs(By similarity). Immunogen:basic leucine zipper transcription factor, ATF-like Synonyms: Observed MW:15 kDa Uniprot ID:Q16520 Reactivity:, Mouse, Rat Tested Application:ELISA, IF, WB Recommended dilution:WB: 1:500-1:1000; IF: 1:10-1:100 Gene ID:10538 Research Area:Epigenetics, Metabolism