ELISA ATF6 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transmembrane glycoprotein of the endoplasmic reticµLum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticµLum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. CoµLd also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. Immunogen:activating transcription factor 6 Synonyms:ATF6, ATF6 alpha, ATF6A Observed MW:90 kDa Uniprot ID:P18850 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 Gene ID:22926 Research Area:Signal Transduction, Metabolism