ELISA Acetylated tubulin(Lys40) anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:6A10 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:TubµLin, composed of heterodimers of alpha and beta tubµLin, is the mainly component of microtubµLes which play important roles in cell motility, mitosis, and intracellµLar vesicle transport. Both alpha and beta tubµLin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. TubµLin acetylation occurs on lysine-40 at the N-terminal of alpha tubµLin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubµLin deacetylases. Reversible acetylation of alpha tubµLin may be implicated in regµLating microtubµLe stability, cell motility, and axon regeneration. The level of acetylated tubµLin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubµLin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubµLin; it does not recognize non-acetylated tubµLin. Immunogen:tubµLin, alpha 1a Synonyms:Acetylated alpha tubµLin, Acetylated tubµLin, acetylated-a-tubµLin, acetyl-a-tubµLin, alpha tubµLin, Alpha tubµLin 3, tubµLin,TUBA1A Observed MW:52 kDa Uniprot ID:Q71U36 Reactivity:, Mouse, Rat, Dog Tested Application:ELISA, WB, IHC, IF Recommended dilution:WB: 1:500-1:5000; IF: 1:20-1:200; IHC: 1:20-1:200 Gene ID:7846 Research Area:Neuroscience, Cell Division and Proliferation, Metabolism