ELISA CHAF1A anti-

Quantity :100µL Clone Number: Aliases:CAF 1 antibody; CAF 1 subunit A antibody; CAF antibody; CAF I 150 kDa subunit antibody; CAF I p150 antibody; CAF-1 subunit A antibody; CAF-I 150 kDa subunit antibody; CAF-I p150 antibody; CAF1 antibody; CAF1A_ antibody; CAF1B antibody; CAF1P150 antibody; CHAF1A antibody; Chromatin assembly factor 1 subunit A antibody; Chromatin Assembly Factor 1 Subunit A p150 antibody; Chromatin assembly factor I (150 kDa) antibody; Chromatin assembly factor I 150 kDa antibody; Chromatin assembly factor I p150 subunit antibody; DCAF1 antibody; hp150 antibody; MGC71229 antibody; P150 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13111 Immunogen:SyntheQuantityd peptide derived from internal of CAF1A. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200 Background:Core component of the CAF-1 complex, a complex thoµght to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly syntheQuantityd histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly syntheQuantityd cbx proteins to heterochromatic DNA replication foci By similarity. Also involved in vitamin D-coupled transcription regµLation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Dong H., Gene 264:187-196(2001) [PubMed: 11250073]. Grimwood J., Nature 428:529-535(2004) [PubMed: 15057824]. Kaufman P.D., Cell 81:1105-1114(1995) [PubMed: 7600578]. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CHAF1A Research Areas:Epigenetics and Nuclear Signaling