ELISA CISH anti-

Quantity :50µL Clone Number: Aliases:BACTS2 antibody; cis 1 antibody; CIS antibody; CIS-1 antibody; CIS1 antibody; Cish antibody; CISH_ antibody; Cytokine inducible inhibitor of signaling type 1B antibody; Cytokine inducible SH2 containing protein antibody; Cytokine-inducible SH2-containing protein antibody; G18 antibody; Protein G18 antibody; SOCS antibody; Suppressor of cytokine signaling antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NSE2 Immunogen:Recombinant Cytokine-inducible SH2-containing protein (1-257AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:SOCS family proteins form part of a classical negative feedback system that regµLates cytokine signal transduction. CIS is involved in the negative regµLation of cytokines that signal throµgh the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CISH Research Areas:Epigenetics and Nuclear Signaling; Signal transduction