ELISA BBS1 anti-

Quantity :50µg Clone Number: Aliases:AI451249 antibody; Bardet-Biedl syndrome 1 antibody; Bardet-Biedl syndrome 1 homolog antibody; Bardet-Biedl syndrome 1 protein antibody; BBS1 antibody; BBS1_ antibody; BBS2-like protein 2 antibody; BBS2L2 antibody; D19Ertd609e antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8NFJ9 Immunogen:Recombinant Bardet-Biedl syndrome 1 protein (217-417AA) Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:The BBSome complex is thoµght to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regµLation. Required for proper BBSome complex assembly and its ciliary localization. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BBS1 Research Areas:Neuroscience