ELISA BCAS4 anti-

Quantity :50µL Clone Number: Aliases:BCAS4Breast carcinoma-amplified sequence 4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TDM0 Immunogen:Synthetic peptide of BCAS4 Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:15-1:50 Background:The gene encoding BCAS4 (Breast carcinoma-amplified sequence 4), a 211 amino acid protein, is found in a region on chromosome 20 that is frequently amplified in breast cancer. This 20q13 locus amplification is found in 12%–39% of primary breast tumors, which correlates with a 17q23 locus amplification that is found in 20% of primary breast tumors. The amplification and translocation between the BCAS4 gene and the BCAS3 gene, with a 17q23 locus, resµLts in a fusion transcript that is overexpressed in MCF-7 cells. Also, deletion of chromosomal region 20q13.13-q13.2 and resµLtant deletion of BCAS4, as well as three other genes, is the cause of Okihiro syndrome, a disease characterized by ocµLar and upper limb anomalies. BCAS4 is normally expressed in thymus, kidney, spleen, placenta and brain. There are three isoforms of BCAS4 which are produced as a resµLt of alternative splicing events. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BCAS4 Research Areas:Cancer