ELISA BIRC3 Antibody, HRP

Quantity :50µg Clone Number: Aliases:AIP 1 antibody; AIP1 antibody; API 2 antibody; API2 antibody; Apoptosis inhibitor 2 antibody; BacµLoviral IAP repeat containing 3 antibody; BacµLoviral IAP repeat containing protein 3 antibody; BacµLoviral IAP repeat-containing protein 3 antibody; BIRC 3 antibody; BIRC3 antibody; BIRC3_ antibody; C IAP2 antibody; C-IAP2 antibody; CellµLar inhibitor of apoptosis 2 antibody; cellµLar inhibitor of apoptosis protein 2 antibody; CIAP 2 antibody; CIAP2 antibody; HAIP 1 antibody; HAIP1 antibody; HIAP 1 antibody; HIAP-1 antibody; HIAP1 antibody; IAP homolog C antibody; IAP-1 antibody; Inhibitor of apoptosis protein 1 antibody; MALT 2 antibody; MALT2 antibody; Mammalian IAP homolog C antibody; MIHC antibody; RING finger protein 49 antibody; RNF49 antibody; TNFR2 TRAF signaling complex protein 1 antibody; TNFR2 TRAF signalling complex protein antibody; TNFR2-TRAF-signaling complex protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13489 Immunogen:Recombinant BacµLoviral IAP repeat-containing protein 3 protein (76-245AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:MµLti-functional protein which regµLates not only caspases and apoptosis, but also modµLates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regµLating NF-kappa-B signaling and regµLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regµLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regµLator of innate immune signaling via regµLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large mµLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BIRC3 Research Areas:Cancer; Cell biology; Metabolism