ELISA BIRC2 anti-

Quantity :50µL Clone Number: Aliases:API 1 antibody; API1 antibody; Apoptosis inhibitor 1 antibody; BacµLoviral IAP repeat containing 2 antibody; BacµLoviral IAP repeat containing protein 2 antibody; BacµLoviral IAP repeat-containing protein 2 antibody; BIRC 2 antibody; BIRC2 antibody; BIRC2_ antibody; C IAP1 antibody; C-IAP1 antibody; CellµLar inhibitor of apoptosis 1 antibody; cellµLar inhibitor of apoptosis protein 1 antibody; cIAP 1 antibody; cIAP1 antibody; HIAP 2 antibody; HIAP-2 antibody; HIAP2 antibody; IAP 2 antibody; IAP homolog B antibody; IAP-2 antibody; IAP2 antibody; Inhibitor of apoptosis protein 2 antibody; MIHB antibody; NFR2 TRAF signalling complex protein antibody; RING finger protein 48 antibody; RNF 48 antibody; RNF48 antibody; TNFR2 TRAF signaling complex protein 2 antibody; TNFR2-TRAF-signaling complex protein 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13490 Immunogen:Recombinant BacµLoviral IAP repeat-containing protein 2 protein (1-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200 Background:MµLti-functional protein which regµLates not only caspases and apoptosis, but also modµLates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regµLating NF-kappa-B signaling and regµLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regµLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjµgation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regµLator of innate immune signaling via regµLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large mµLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimµLate the transcriptional activity of E2F1. Plays a role in the modµLation of the cell cycle. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BIRC2 Research Areas:Cancer; Cell biology; Metabolism