ELISA BMP10 anti-

Quantity :100µL Clone Number: Aliases:BMP-10 antibody; Bmp10 antibody; BMP10_ antibody; Bone morphogenetic protein 10 antibody; Bone morphogenetic protein 10 preproprotein antibody; MGC126783 antibody; OTTHUMP00000159973 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95393 Immunogen:SyntheQuantityd peptide derived from Internal of BMP10. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regµLator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Celeste A.J., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. Hillier L.W., Nature 434:724-731(2005). Mazerbourg S., J. Biol. Chem. 280:32122-32132(2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BMP10 Research Areas:CardiovascµLar;Signal transduction