ELISA ATF6 anti-

Quantity :50µL Clone Number: Aliases:activating transcription factor 6 Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P18850 Immunogen:Synthetic peptide of ATF6 Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 Background:This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticµLum (ER) stress. Althoµgh it is a transcription factor, this protein is unusual in that it is syntheQuantityd as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different popµLations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thoµght to be a potential therapeutic target for cystic fibrosis. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ATF6 Research Areas:Epigenetics and Nuclear Signaling