ELISA BAX anti-

Quantity :100µL Clone Number: Aliases:Apoptosis regµLator BAX; BAX; Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q07814 Immunogen:SyntheQuantityd peptide derived from internal of BAX. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 Background:The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regµLators that are involved in a wide variety of cellµLar activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regµLated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. MµLtiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. Oltvai Z.N., Cell 74:609-619(1993). Apte S.S., Genomics 26:592-594(1995). Shi B., Biochem. Biophys. Res. Commun. 254:779-785(1999). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BAX Research Areas:Cancer;Cell biology;Metabolism