ELISA BARD1 anti-

Quantity :100µL Clone Number: Aliases:BARD-1 antibody; Bard1 antibody; BARD1_ antibody; BRCA1 associated RING domain 1 antibody; BRCA1 associated RING domain gene 1 antibody; BRCA1 associated RING domain protein 1 antibody; BRCA1-associated RING domain protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99728 Immunogen:SyntheQuantityd peptide derived from N-terminal of BARD1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellµLar pathways such as DNA damage repair, ubiquitination and transcriptional regµLation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modµLate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Wu L.C., Nat. Genet. 14:430-440(1996). Thai T.H., Hum. Mol. Genet. 7:195-202(1998). Hillier L.W., Nature 434:724-731(2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BARD1 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Metabolism