ELISA CHP1 anti-

Quantity :100µL Clone Number: Aliases:Calcineurin B homolog antibody; Calcineurin B homologous protein antibody; Calcineurin homologous protein antibody; Calcineurin like EF hand protein 1 antibody; Calcium binding protein CHP antibody; Calcium binding protein p22 antibody; Calcium-binding protein CHP antibody; Calcium-binding protein p22 antibody; chp antibody; CHP1_ antibody; Sid 470 antibody; Sid470 antibody; SLC9A1 binding protein antibody; SLC9A1BP antibody; Wrch2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99653 Immunogen:SyntheQuantityd peptide derived from N-terminal of CHP. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Calcium-binding protein involved in different processes such as regµLation of vesicµLar trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubµLes and membrane-bound organelles of the endoplasmic reticµLum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regµLation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimµLated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regµLator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regµLates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner. Lin X., Proc. Natl. Acad. Sci. U.S.A. 93:12631-12636(1996). Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. Ota T., Nat. Genet. 36:40-45(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CHP1 Research Areas:Cancer;Metabolism;Signal transduction