ELISA DDIT3 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:C/EBP homologous protein antibody; C/EBP Homology Protein antibody; C/EBP zeta antibody; C/EBP-homologous protein 10 antibody; C/EBP-homologous protein antibody; CCAAT/enhancer binding protein homologous protein antibody; CEBPZ antibody; CHOP 10 antibody; CHOP antibody; CHOP-10 antibody; CHOP10 antibody; DDIT 3 antibody; DDIT-3 antibody; Ddit3 antibody; DDIT3_ antibody; DNA Damage Inducible Transcript 3 antibody; DNA damage-inducible transcript 3 protein antibody; GADD 153 antibody; GADD153 antibody; Growth Arrest and DNA Damage Inducible Protein 153 antibody; Growth arrest and DNA damage inducible protein GADD153 antibody; Growth arrest and DNA damage-inducible protein GADD153 antibody; MGC4154 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P35638 Immunogen:Recombinant DNA damage-inducible transcript 3 protein (1-169AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:MµLtifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regµLator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regµLated genes. Positively regµLates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regµLates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regµLatory role in the inflammatory response throµgh the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DDIT3 Research Areas:Epigenetics and Nuclear Signaling; Developmental biology; Metabolism; Stem cells