ELISA DAPK1 anti-

Quantity :50µL Clone Number: Aliases:DAK1 antibody; DAP K1 antibody; DAP kinase 1 antibody; DAPK 1 antibody; DAPK antibody; DAPK1 antibody; DAPK1_ antibody; Death Associated Protein Kinase 1 antibody; Death-associated protein kinase 1 antibody; DKFZp781I035 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P53355 Immunogen:Recombinant Death-associated protein kinase 1 protein (1141-1430AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Calcium/calmodµLin-dependent serine/threonine kinase involved in mµLtiple cellµLar signaling pathways that trigger cell survival, apoptosis, and autophagy. RegµLates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellµLar setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumµLation of autophagic vesicles. Phosphorylates PIN1 resµLting in inhibition of its catalytic activity, nuclear localization, and cellµLar function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regµLates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimµLating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx throµgh NMDA receptor channels, resµLting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DAPK1 Research Areas:Cancer; Cell biology; Signal transduction