ELISA CSNK2A1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Casein kinase 2 alpha 1 polypeptide antibody; Casein kinase II alpha 1 antibody; Casein kinase II alpha 1 subunit antibody; Casein kinase II alpha subunit antibody; Casein kinase II subunit alpha antibody; CK II alpha antibody; CK II antibody; CK2 alpha antibody; CK2 catalytic subunit alpha antibody; CK2A1 antibody; CKII antibody; CKIIalpha antibody; CSK21_ antibody; CSNK2A1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P68400 Immunogen:Recombinant Casein kinase II subunit alpha protein (1-391AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. RegµLates numerous cellµLar processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regµLatory node which integrates and coordinates numerous signals leading to an appropriate cellµLar response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating \\\'Ser-392\\\' of p53/TP53 following UV irradiation. Can also negatively regµLate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regµLator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. RegµLates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regµLates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. RegµLates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellµLar proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PmL at \\\'Ser-565\\\' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at \\\'Ser-90\\\' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CSNK2A1 Research Areas:Cell biology; Signal transduction