ELISA CNOT1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:CNOT1 antibody; CDC39 antibody; KIAA1007 antibody; NOT1 antibody; AD-005CCR4-NOT transcription complex subunit 1 antibody; CCR4-associated factor 1 antibody; Negative regµLator of transcription subunit 1 homolog antibody; NOT1H antibody; hNOT1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:A5YKK6 Immunogen:Recombinant CCR4-NOT transcription complex subunit 1 protein (604-867AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Scaffolding component of the CCR4-NOT complex which is one of the major cellµLar mRNA deadenylases and is linked to various cellµLar processes including bµLk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regµLation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex modµLe and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CNOT1 Research Areas:Others