ELISA BMX anti-

Quantity :50µL Clone Number: Aliases:Bmx antibody; BMX non receptor tyrosine kinase antibody; BMX_ antibody; BONE MARROW KINASE; X-LINKED antibody; Bone marrow tyrosine kinase gene in chromosome X protein antibody; Cytoplasmic tyrosine protein kinase BMX antibody; Cytoplasmic tyrosine-protein kinase BMX antibody; Epithelial and endothelial tyrosine kinase antibody; ETK antibody; NKT38 antibody; NTK 38 antibody; NTK38 antibody; Protein tyrosine kinase BMX antibody; PSCTK 2 antibody; PSCTK 3 antibody; PSCTK2 antibody; PSCTK3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P51813 Immunogen:Recombinant Cytoplasmic tyrosine-protein kinase BMX protein (65-280AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Non-receptor tyrosine kinase that plays central but diverse modµLatory roles in various signaling processes involved in the regµLation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimµLated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regµLation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regµLation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellµLar stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regµLation of endocytosis throµgh its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BMX Research Areas:Signal transduction