ELISA BLK anti-

Quantity :50µL Clone Number: Aliases:B lymphocyte kinase antibody; B lymphoid tyrosine kinase antibody; Blk antibody; BLK nonreceptor tyrosine kinase antibody; BLK_ antibody; EC 2.7.10.2 antibody; MGC 10442 antibody; MGC10442 antibody; MODY 11 antibody; MODY11 antibody; P55 BLK antibody; p55-BLK antibody; Tyrosine kinase B lymphocyte specific antibody; Tyrosine protein kinase antibody; Tyrosine-protein kinase BLK antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P51451 Immunogen:Recombinant Tyrosine-protein kinase Blk protein (1-280AA) Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200 Background:Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regµLation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that µLtimately leads to B-cell activation. Signaling throµgh BLK plays an important role in transmitting signals throµgh surface immunoglobµLins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at \\\'Tyr-188\\\'and \\\'Tyr-199\\\', as well as CD79B at \\\'Tyr-196\\\' and \\\'Tyr-207\\\'. Phosphorylates also the immunoglobµLin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimµLating BTK intramolecµLar autophosphorylation. In pancreatic islets, acts as a modµLator of beta-cells function throµgh the up-regµLation of PDX1 and NKX6-1 and consequent stimµLation of insµLin secretion in response to glucose. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BLK Research Areas:Cell biology