ELISA ATP8B1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:AT8B1_ antibody; ATP8B1 antibody; ATPase class I type 8B member 1 antibody; ATPase; aminophospholipid transporter; class I; type 8B; member 1 antibody; ATPIC antibody; BRIC antibody; E1-E2 ATPase antibody; Familial intrahepatic cholestasis type 1 antibody; FIC1 antibody; OTTHUMP00000163615 antibody; PFIC antibody; PFIC1 antibody; Phospholipid transporting ATPase IC antibody; Probable phospholipid-transporting ATPase IC antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43520 Immunogen:Recombinant Phospholipid-transporting ATPase IC protein (217-330AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecµLes. May play a role in asymmetric distribution of phospholipids in the canicµLar membrane. May have a role in transport of bile acids into the canalicµLus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicµLar membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drµg alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ATP8B1 Research Areas:Signal transduction