ELISA ATG7 anti-

Quantity :50µg Clone Number: Aliases:1810013K23Rik antibody; Apg 7 antibody; APG7 autophagy 7 like antibody; APG7 autophagy 7-like (S. cerevisiae) antibody; APG7 like antibody; APG7; S. cerevisiae; homolog of antibody; APG7-like antibody; APG7L antibody; ATG 7 antibody; ATG12-activating enzyme E1 ATG7 antibody; ATG7 antibody; ATG7 autophagy related 7 homolog (S. cerevisiae) antibody; ATG7 autophagy related 7 homolog antibody; ATG7_ antibody; Atg7l antibody; Autophagy 7; S. cerevisiae; homolog of antibody; Autophagy related protein 7 antibody; Autophagy-related 7 (yeast) antibody; Autophagy-related protein 7 antibody; DKFZp434N0735 antibody; GSA 7 antibody; GSA7 antibody; hAGP7 antibody; Ubiquitin activating enzyme E1 like protein antibody; Ubiquitin-activating enzyme E1-like protein antibody; Ubiquitin-like modifier-activating enzyme ATG7 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95352 Immunogen:Recombinant Ubiquitin-like modifier-activating enzyme ATG7 protein (386-676AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjµgation with ATG5 as well as the ATG8 family proteins for their conjµgation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regµLate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fµLfill cellµLar energy requirements and preventing excess ROS production. ModµLates p53/TP53 activity to regµLate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granµLes, as well as in adipose differentiation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ATG7 Research Areas:Cancer; CardiovascµLar; Cell biology; Metabolism; Signal transduction