ELISA beta-Catenin anti-

Quantity:100µg Purification:protein A+G purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:5D7 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regµLating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medµLloblastoma (MDB), and ovarian cancer. Alternative splicing resµLts in mµLtiple transcript variants. Immunogen:catenin(cadherin-associated protein), beta 1, 88kDa Synonyms:b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, ? catenin, ?-catenin Observed MW:90 kDa Uniprot ID:P35222 Reactivity:, Mouse, Rat, Pig Tested Application:ELISA, IF, WB, IHC, IP Recommended dilution:WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500 Gene ID:1499 Research Area:Epigenetics, Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells