ELISA CSK anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Non-receptor tyrosine-protein kinase that plays an important role in the regµLation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecµLar interactions between the phosphotyrosine tail and the SH2 domain that resµLt in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Immunogen:c-src tyrosine kinase
Synonyms:
Observed MW:50 kDa
Uniprot ID:P41240
Reactivity:
Tested Application:ELISA, WB, IHC, IF, IP
Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Gene ID:1445
Research Area:Immunology, Signal Transduction, Metabolism
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