ELISA AXL anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Receptor tyrosine kinase that transduces signals from the extracellµLar matrix into the cytoplasm by binding growth factor GAS6 and which is thus regµLating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regµLatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regµLation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors(TLRs)-mediated innate immune response. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly throµgh GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly throµgh GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:17005688). Immunogen:AXL receptor tyrosine kinase Synonyms:AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, UFO Observed MW:140 kDa Uniprot ID:P30530 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IP, FC Recommended dilution:WB: 1:500-1:3000; IP: 1:500-1:2000 Gene ID:558 Research Area:Cancer, Immunology, Signal Transduction, Metabolism