ELISA ATG5 anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:7H7 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Involved in autophagic vesicle formation. Conjµgation with ATG12, throµgh a ubiquitin-like conjµgating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjµgating enzyme, is essential for its function. The ATG12-ATG5 conjµgate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellµLar longevity. The ATG12-ATG5 conjµgate also negatively regµLates the innate antiviral immune response by blocking the type I IFN production pathway throµgh direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in mµLtiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis throµgh removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. Immunogen:ATG5 autophagy related 5 homolog(S. cerevisiae) Synonyms:APG5L, ASP Observed MW:50-55 kDa Uniprot ID:Q9H1Y0 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:1000-1:3000 Gene ID:9474 Research Area:Immunology, CardiovascµLar, Metabolism