ELISA AMACR|p504S anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regµLated at the transcript and protein level in hormone-refractory metastatic PCa, sµggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4). Immunogen:alpha-methylacyl-CoA racemase Synonyms:2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE Observed MW:42 kDa Uniprot ID:Q9UHK6 Reactivity:, rat Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200 Gene ID: Research Area:Stem Cells, Immunology, Metabolism, Cancer