ELISA Alpha-1-Antitrypsin anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:5B1 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:SERPINA1 is the gene for a protein called alpha-1-antitrypsin(AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein syntheQuantityd primarily by hepatocytes, with smaller amountssyntheQuantityd by intestinal epithelial cells, neutrophils, pµLmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circµLation and it has been implicated in regµLating vital fluid phase biological events such as blood coagµLation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thoµght to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease. Immunogen:serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1 Synonyms:A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, ?1-antitrypsin Observed MW:50 kDa Uniprot ID:P01009 Reactivity:, Rat Tested Application:ELISA, WB, IHC, IF Recommended dilution:WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000 Gene ID:5265 Research Area:Cancer, Immunology, CardiovascµLar, Metabolism