ELISA ADAM17-Specific anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:The ADAMs(A Disintegrin And Metalloprotease) are mµLtidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The fµLl length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17. Immunogen:ADAM metallopeptidase domain 17 Synonyms:ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme Observed MW:29 kDa Uniprot ID:P78536 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200 Gene ID:6868 Research Area:Signal Transduction, Metabolism, CardiovascµLar, Immunology, Developmental biology, Neuroscience