ELISA CREB1 (Ab-129) anti-

Quantity :100µL Clone Number: Aliases:Active transcription factor CREB antibody; cAMP response element binding protein 1 antibody; cAMP response element binding protein antibody; cAMP responsive element binding protein 1 antibody; cAMP-responsive element-binding protein 1 antibody; CREB antibody; CREB-1 antibody; CREB1 antibody; CREB1_ antibody; Cyclic AMP-responsive element-binding protein 1 antibody; MGC9284 antibody; OTTHUMP00000163864 antibody; OTTHUMP00000163865 antibody; OTTHUMP00000206660 antibody; OTTHUMP00000206662 antibody; OTTHUMP00000206667 antibody; Transactivator protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P16220 Immunogen:Peptide sequence around aa.127~131 (I-L-S-R-R) derived from CREB. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background:CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimµLation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories Chrystelle V. Garat, et al. (2006) Mol. Cell. Biol ; 26: 4934 - 4948. Lilah Rothem,et al. (2004) Mol. Pharmacol ; 66: 1536 - 1543. Darren R. Tyson, et,al. (2002) Endocrinology; 143: 674. Kyung-Woo Park, et al. (2003) Arterioscler. Thromb. Vasc. Biol ; 23: 1364. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CREB1 Research Areas:Epigenetics and Nuclear Signaling;Immunology