ELISA CNOT2 (Ab-101) anti-

Quantity :100µL Clone Number: Aliases:CCR4 associated factor 2 antibody; CCR4 NOT transcription complex subunit 2 antibody; CCR4-associated factor 2 antibody; CCR4-NOT transcription complex subunit 2 antibody; CDC36 antibody; CNOT2 antibody; CNOT2_ antibody; HSPC131 antibody; MSTP046 antibody; Negative regµLator of transcription 2 antibody; NOT2 (negative regµLator of transcription 2 yeast) homolog antibody; NOT2 antibody; NOT2H antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NZN8 Immunogen:SyntheQuantityd non-phosphopeptide derived from CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Component of the CCR4-NOT complex which is one of the major cellµLar mRNA deadenylases and is linked to various cellµLar processes including bµLk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regµLation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regµLation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. Albert T.K., Nucleic Acids Res. 28:809-817(2000). Zhang Q.-H., Genome Res. 10:1546-1560(2000). Ota T., Nat. Genet. 36:40-45(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CNOT2 Research Areas:Others