ELISA CREBBP anti-

Quantity :100µL Clone Number: Aliases:CBP antibody; CBP_ antibody; CREB binding protein antibody; CREB-binding protein antibody; Crebbp antibody; Cyclic AMP responsive enhancer binding protein antibody; KAT3A antibody; RSTS antibody; RTS antibody; Rubinstein Taybi syndrome antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92793 Immunogen:SyntheQuantityd peptide derived from CREB-BP. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 Background:Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 - 5340. Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 - 55681. Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051. Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19 Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CREBBP Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism?Microbiology;Stem cells