ELISA BOK anti-

Quantity :50µg Clone Number: Aliases:Bcl 2 related ovarian killer protein antibody; Bcl-2-like protein 9 antibody; Bcl-2-related ovarian killer protein antibody; BCL2 related ovarian killer antibody; Bcl2-L-9 antibody; BCL2L9 antibody; BOK antibody; BOK_ antibody; BOKL antibody; Hbok antibody; MGC4631 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UMX3 Immunogen:Recombinant Bcl-2-related ovarian killer protein (15-103AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Isoform 1: Apoptosis regµLator that functions throµgh different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regµLates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticµLum stress promotes mitochondrial apoptosis throµgh downstream BAX/BAK1 activation and positive regµLation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 throµgh induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resµLting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granµLosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apototic process, by negatively regµLating poly ADP-ribose polymerase-dependent cell death throµgh regµLation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regµLate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition throµgh regµLation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BOK Research Areas:Cell biology