ELISA CHP2 anti-

Quantity :100µL Clone Number: Aliases:CHP2 antibody; HCA520Calcineurin B homologous protein 2 antibody; HepatocellµLar carcinoma-associated antigen 520 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43745 Immunogen:SyntheQuantityd peptide derived from internal of CHP2. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Functions as an integral cofactor in cell pH regµLation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regµLation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. Loftus B.J., Genomics 60:295-308(1999). Wang Y., J. Immunol. 169:1102-1109(2002). Pang T., J. Biol. Chem. 277:43771-43777(2002). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CHP2 Research Areas:Others