ELISA BARD1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:BARD-1 antibody; Bard1 antibody; BARD1_ antibody; BRCA1 associated RING domain 1 antibody; BRCA1 associated RING domain gene 1 antibody; BRCA1 associated RING domain protein 1 antibody; BRCA1-associated RING domain protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99728 Immunogen:Recombinant BRCA1-associated RING domain protein 1 protein (428-777AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of \'Lys-6\'-linked polyubiquitin chains and coordinates a diverse range of cellµLar pathways such as DNA damage repair, ubiquitination and transcriptional regµLation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modµLate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3\' cleavage. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BARD1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism