ELISA AIM2 anti-

Quantity :50µL Clone Number: Aliases:Absent in melanoma 2 antibody; AIM 2 antibody; Aim2 antibody; AIM2_ antibody; Interferon-inducible protein AIM2 antibody; OTTHUMP00000035296 antibody; PYHIN4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14862 Immunogen:Fusion protein of AIM2 Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:50-1:200 Background:Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN- , AIM2 is thoµght to act as a tumor suppressor by repressing NF B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, resµLts in the activation of Caspase-1. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AIM2 Research Areas:Epigenetics and Nuclear Signaling;Cancer