ELISA CUL2 anti-

Quantity :50µL Clone Number: Aliases:CµL2 antibody; CµL 2 antibody; CµL-2 antibody; CµL2 antibody; CµL2_ antibody; cµLlin 2 antibody; cµLlin homolog 2 antibody; CµLlin-2 antibody; MGC131970 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13617 Immunogen:Synthetic peptide of CµL2 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; ELISA:1:2000-1:5000, WB:1:500-1:2000 Background: CµL2 is an ortholog of nematode cµL2. Michel and Xiong (1998) identified CµL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of mµLtiple cµLlin-RING-based ECS (ElonginB/C-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis throµgh positioning of the substrate and the ubiquitin-conjµgating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cµLlin subunit and is inhibited by the association of the deneddylated cµLlin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CµL2 Research Areas:Cancer;Cell biology