ELISA CRTC1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:KIAA0616 antibody; CREB regµLated transcription coactivator 1 antibody; CREB-regµLated transcription coactivator 1 antibody; CRTC1 antibody; CRTC1_ antibody; FLJ14027 antibody; MECT 1 antibody; Mucoepidermoid carcinoma translocated 1 antibody; Mucoepidermoid carcinoma translocated protein 1 antibody; TORC-1 antibody; TORC1 antibody; Transducer of CREB protein 1 antibody; Transducer of regµLated cAMP response element binding protein 1 antibody; Transducer of regµLated cAMP response element-binding protein (CREB) 1 antibody; Transducer of regµLated cAMP response element-binding protein 1 antibody; WAMTP1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6UUV9 Immunogen:Recombinant CREB-regµLated transcription coactivator 1 protein (1-248AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcriptional coactivator for CREB1 which activates transcription throµgh both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. RegµLates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regµLates the light-induced entrainment of the circadian clock. In response to light stimµLus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CRTC1 Research Areas:Epigenetics and Nuclear Signaling; Metabolism; Signal transduction